Central West End Commercial Office Space for Rent

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Central West End

Renting Commercial Office Space in Central West End

The Central West End remains the "Trophy" submarket of St. Louis. Anchored by the world-class BJC Healthcare/Washington University Medical Center and the Cortex Innovation District, it is the region's primary engine for high-paying tech and medical jobs. In early 2026, the neighborhood is seeing premium rent growth (averaging $2,100–$2,600/month) and remains the top choice for luxury apartment conversions (Source: House Sold Easy 2026 Outlook). 2026 marks a year of "Innovation Maturity." As the Cortex district surpasses 500 companies, the demand for high-end executive housing in the CWE is reaching a ten-year peak. It remains the safest "legacy" investment in the city, offering unmatched stability and a highly educated tenant base of doctors and researchers.

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Popular Properties in the Central West End Neighborhood

La Beaume

3,500 SF

$1,400 /mo

Warehouse

S 4th Street

215 – 2,000 SF

$800 – $450,000 /mo

General

Deloitte Building

1,521 – 114,000 SF

$2,300 – $175,800 /mo

General

Duncan Ave

16,751 – 59,000 SF

$36,300 – $73,800 /mo

General

Locust St

750 – 29,191 SF

$900 – $34,100 /mo

Chippewa

39,780 SF

$16,400 /mo

Warehouse

Clayton Plaza - Office

339 – 10,262 SF

$600 – $19,700 /mo

General

Strassner Drive

3,241 – 7,500 SF

$3,200 – $7,500 /mo

Strassner Drive

5,515 – 19,569 SF

$5,500 – $19,600 /mo

General

Design Way

40,000 – 210,560 SF

$14,200 – $74,600 /mo

Warehouse

Mississippi Ave

1,500 – 11,856 SF

$1,600 – $12,800 /mo

Storefront

Belt Avenue

2,300 SF

$3,000 /mo

Storefront

Turnkey Restaurant Space in the Heart of The Grove!

2,200 SF

$4,600 /mo

Restaurant

Former Church's Chicken Available for Lease

1,700 SF

- /mo

General

Hanley Industrial Court

11,000 SF

$11,000 /mo

Warehouse

Suite Rates in Central West End

Suite Sizes in Central West End

Neighborhood Comparison

Neighborhood	Average Available SQFT	Average Rate / SQFT PER Month	NUMBER OF AVAILABLE SUITES
Airport	2,200	$1.35 / SF	147
Chesterfield	2,000	$1.68 / SF	365
Downtown St Louis	2,500	$1.43 / SF	202
Fairview Heights	2,600	$0.97 / SF	99
Ferguson	4,400	$0.66 / SF	< 30
Midtown St Louis	2,500	$1.43 / SF	206
O'Fallon	2,100	$1.21 / SF	40
St Charles	2,200	$1.33 / SF	159

*All data is from sources we deem reliable and is tracked to provide tenants an understanding of market and submarket conditions, however we cannot guarantee accuracy and all data should be confirmed prior to any use in the lease or purchase of real property.